Altered function in medial prefrontal cortex and nucleus accumbens links to stress-induced behavioral inflexibility

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Altered function in medial prefrontal cortex and nucleus accumbens links to stress-induced behavioral inflexibility

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作者：Chengji Piao^a ; ^b ; ^c ; Xiaofei Deng^a ; ^b ; ¹ ; Xingyue Wang^a ; ^b ; ¹ ; Yiran Yuan^d ; Zhengkui Liu^a ; Jing Liang^a ; ^{liangj@psych.ac.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：Single prolonged stress ; Set-shifting ; Medial prefrontal cortex ; Nucleus accumbens
刊名：Behavioural Brain Research
出版年：2017
出版时间：15 January 2017
年：2017
卷：317
期：Complete
页码：16-26
全文大小：3045 K

文摘

•: Single prolonged stress (SPS) impaired set-shifting.
•: SPS-induced set-shifting impairments coincided with activity reduction in NAc core.
•: Neurons in mPFC exhibited higher activity in SPS-induced set-shifting dysfunction.
•: Enhanced phospho-GluA1-Ser845 in mPFC was related to the impaired set-shifting.

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