Berberine in combination with yohimbine attenuates sepsis-induced neutrophil tissue infiltration and multiorgan dysfunction partly via IL-10-mediated inhibition of CCR2 expression in neutrophils

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Berberine in combination with yohimbine attenuates sepsis-induced neutrophil tissue infiltration and multiorgan dysfunction partly via IL-10-mediated inhibition of CCR2 expression in neutrophils

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作者：Yuan Wang¹ ; Faqiang Wang¹ ; Duomeng Yang ; Xiangxu Tang ; Hongmei Li ; Xiuxiu Lv ; Daxiang Lu ; Huadong Wang ; ^{owanghd@jnu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：Berberine ; Yohimbine ; Sepsis ; IL-10 ; Chemokine receptor CCR2
刊名：International Immunopharmacology
出版年：2016
出版时间：June 2016
年：2016
卷：35
期：Complete
页码：217-225
全文大小：1234 K

文摘

•: Berberine and yohimbine therapy up-regulates IL-10 expression in septic mice.
•: Berberine and yohimbine reduce CLP-induced neutrophil tissue infiltration via IL-10.
•: Berberine and yohimbine attenuate CLP-induced multiple organ damage via IL-10.
•: Berberine and yohimbine inhibit CLP-induced CCR2 expression in neutrophils via IL-10.

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