Therapeutic Activity of Agonistic, Human Anti-CD40 Monoclonal Antibodies Requires Selective FcγR Engagement
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<p id="p0010">Wild-type mice fail to model the activity of human CD40 IgG subclassesp>
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<p id="p0015">Humanized FcγR/CD40 mice enabled assessment of hFcR contribution to CD40 mAb activityp>
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<p id="p0020">Binding affinity to FcγRIIB dictates the agonistic activity of human CD40 IgGsp>
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<p id="p0025">CD40 mAbs enhanced for FcγRIIB, but not FcγRIIA, have optimal antitumor activityp>
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