PTEN methylation involved in benzene-induced hematotoxicity

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PTEN methylation involved in benzene-induced hematotoxicity

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作者：Jing Yang¹ ; Xin Zuo¹ ; Wenlin Bai ; Piye Niu ; Lin Tian ^{tianlin@ccmu.edu.cn" class="auth_mail} ; Ai Gao ; ^{gaoai0980@163.com" class="auth_mail}
关键词：Benzene ; PTEN ; Epigenetic modifications ; Hematotoxicity ; Methylation-specific PCR
刊名：Experimental and Molecular Pathology
出版年：June 2014
年：2014
卷：96
期：3
页码：300-306
全文大小：715 K

文摘

•: A dramatic decrease in the PTEN mRNA expression and a significant increase of PTEN methylation level were shown in benzene-treated rats and F32 lymphoblast cell line cells.
•: PTEN mRNA expression was up regulated and PTEN methylation level was reduced by the epigenetic inhibitors, 5-aza and TSA.
•: PTEN methylation is involved in benzene-induced hematotoxicity through suppressing PTEN mRNA expression.

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