Suppressed osteoclast differentiation at the chondro-osseous junction mediates endochondral ossification retardation in long bones of Wistar fetal rats with prenatal ethanol exposure

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Suppressed osteoclast differentiation at the chondro-osseous junction mediates endochondral ossification retardation in long bones of Wistar fetal rats with prenatal ethanol exposure

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作者：Zhengqi Pan^a ; ^b ; ¹ ; Xianrong Zhang^c ; ¹ ; Yangfan Shangguan^a ; Hang Hu^a ; Liaobin Chen^a ; ^c ; ^{lbchen@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Hui Wang^b ; ^c ; ^{wanghui19@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：BSP ; bone sialoprotein ; GAPDH ; glyceraldehyde phosphate dehydrogenase ; GD ; gestational day ; PEE ; prenatal ethanol exposure ; HPA ; hypothalamus&ndash ; pituitary&ndash ; adrenal ; HZ ; hypertrophy zone ; IUGR ; intrauterine growth retardation ; Mifi ; mifepristone ; OCN ; osteocalcin ; OPG ; osteoprotegerin ; RANKL ; receptor activator for nuclear factor-κb ligand ; POC ; primary ossification center ; PZ ; proliferation zone ; RT-PCR ; real-time quantitative PCR ; TRAP ; tartrate resistant acid phosphatase ; TUNEL ; TdT-me
刊名：Toxicology and Applied Pharmacology
出版年：2016
出版时间：15 August 2016
年：2016
卷：305
期：Complete
页码：234-241
全文大小：1225 K

文摘

•: Glucocorticoid but not ethanol enhanced the expression of OPG in chondrocytes.
•: PEE reduced osteoclast differentiation relative with over-expression of OPG.
•: PEE inhibited endochondral ossification in fetal long bones of rats.
•: Endochondral ossification delay is regarded as the thrifty phenotype induced by PEE.