miR-370 is stage-specifically expressed during mouse embryonic development and regulates Dnmt3a

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• 作者：Liu Qi ; He Hongjuan ; Gu Ning ; Han Zhengbin ; Xing Yanjiang ; Zeng Tiebo ; Huang Zhijun ; Wu Qiong ; ^{kigo@hit.edu.cn}
• 关键词：miR-370 ; Spatiotemporal expression ; Embryonic development ; Dnmt3a
• 刊名：FEBS Letters
• 出版年：2013
• 出版时间：18 March, 2013
• 年：2013
• 卷：587
• 期：6
• 页码：775-781
• 全文大小：1167 K

文摘

MicroRNAs (miRNAs) are small non-coding RNAs that participate in a large variety of biological processes. In this paper, the spatiotemporal expression pattern of miR-370 was characterized during mouse embryonic development, and was found to be stage- and tissue-specifically expressed. In addition, through luciferase reporter assays and western blot analyses, DNA methyltransferase 3A (Dnmt3a) was identified as a directly regulated target of miR-370. Altogether, our results indicate that miR-370 may play important roles in the morphogenesis of diverse organs, especially brain and adrenal glands, by mediating Dnmt3a expression during mouse development.