ATF4 regulates SREBP1c expression to control fatty acids synthesis in 3T3-L1 adipocytes differentiation

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ATF4 regulates SREBP1c expression to control fatty acids synthesis in 3T3-L1 adipocytes differentiation

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作者：Hu Chen ; Renqiang Yuan ; Ying Zhang ; Xumeng Zhang ; Luxi Chen ; Xingyu Zhou ; Zhuning Yuan ; Yaping Nie ; Ming Li ; Delin Mo ; ^{modelin@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Yaosheng Chen ; ^{chyaosh@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：USP7 ; ubiquitin specific peptidase 7 ; TRB3 ; tribbles homolog 3 ; PTM ; post-translational modification ; IBMX ; 1-methyl-3-isobutylxanthine ; DEX ; dexamethasone ; INS ; insulin
刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
出版年：2016
出版时间：November 2016
年：2016
卷：1859
期：11
页码：1459-1469
全文大小：1864 K

文摘

•: Depletion of ATF4 decreased SREBP1c protein while increased Srebp1c mRNA.
•: USP7 was identified as a novel target of ATF4.
•: USP7 deubiquitinated SREBP1c protein and increased its level in cell.
•: ATF4 inhibited Srebp1c transcription via TRB3.
•: TRB3 was repressed by IBMX and DEX at early adipogenesis.

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