Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis

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• 作者：Anja Fleger-Weckmann^a ; ¹ ; Yasemin &Uuml ; st&uuml ; n^a ; ¹ ; Jennifer Kloepper^b ; Ralf Paus^c ; Wilhelm Bloch^d ; Zu-Lin Chen^e ; Jeannine Wegner^f ; ^g ; Lydia Sorokin^f ; ^g ; Lutz Langbein^h ; Beate Eckes^a ; Paola Zigrino^a ; Thomas Krieg^a ; ⁱ ; ^j ; ^{thomas.krieg@uni-koeln.de} ; Roswitha Nischt^a
• 关键词：BM ; basement membrane ; BMP ; bone morphogenetic protein ; DEJ ; dermo-epidermal junction ; E ; embryonic day ; FOXN1 ; Forkhead box N1 ; HF ; hair follicle ; HS ; hair shaft ; HOXC13 ; Homeobox C13 ; IF ; immunofluorescence ; IRS ; inner root sheath ; K5 ; keratin 5 ; K14 ; keratin 14 ; KAPs ; keratin associated proteins ; Lef1 ; lymphoid enhancing factor ; MSX2 ; Homeobox msh-like 2 ; PCR ; polymerase chain reaction ; P ; postnatal day ; RT ; reverse transcriptase ; Shh ; Sonic hedgehog ; TA ; transient amplifying ; TF ; transcripti
• 刊名：Matrix Biology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：56
• 期：Complete
• 页码：42-56
• 全文大小：2502 K
• 卷排序：56

文摘

Hair follicle formation after birth is critically regulated by epidermal laminin γ1 Mice with epidermal deletion of laminin γ1 display retarded hair follicle morphogenesis Hair growth defects correlate with reduced hair matrix cell proliferation and disturbed hair shaft differentiation Modulation of the BMP-MSX2-HOXC13-FOXN1 signaling axis by laminin γ1 contributes to proper hair shaft differentiation