Genomic Sequencing Identifies ELF3 as a Driver of Ampullary Carcinoma

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Genomic Sequencing Identifies ELF3 as a Driver of Ampullary Carcinoma

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作者：Shinichi Yachida¹ ; ²⁰ ; ^{syachida@ncc.go.jp" class="auth_mail" title="E-mail the corresponding author} ; Laura D. Wood² ; Masami Suzuki¹ ; Erina Takai¹ ; Yasushi Totoki¹ ; Mamoru Kato³ ; Claudio Luchini² ; Yasuhito Arai¹ ; Hiromi Nakamura¹ ; Natsuko Hama¹ ; Asmaa Elzawahry³ ; Fumie Hosoda¹ ; Tomoki Shirota¹ ; Nobuhiko Morimoto⁴ ; Kunio Hori⁴ ; Jun Funazaki⁴ ; Hikaru Tanaka⁵ ; Chigusa Morizane⁶ ; Takuji Okusaka⁶ ; Satoshi Nara⁷ ; Kazuaki Shimada⁷ ; Nobuyoshi Hiraoka⁸ ; Hirokazu Taniguchi⁸ ; Ryota Higuchi⁹ ; Minoru Oshima¹⁰ ; Keiichi Okano¹⁰ ; Seiko Hirono¹¹ ; Masamichi Mizuma¹² ; Koji Arihiro¹³ ; Masakazu Yamamoto⁹ ; Michiaki Unno¹² ; Hiroki Yamaue¹¹ ; Matthew J. Weiss¹⁴ ; Christopher L. Wolfgang¹⁴ ; Toru Furukawa¹⁵ ; Hitoshi Nakagama¹⁶ ; Bert Vogelstein² ; ¹⁷ ; Tohru Kiyono¹⁶ ; Ralph H. Hruban² ; ¹⁸ ; Tatsuhiro Shibata¹ ; ¹⁹
刊名：Cancer Cell
出版年：2016
出版时间：8 February 2016
年：2016
卷：29
期：2
页码：229-240
全文大小：4276 K

文摘

•: 172 ampullary carcinomas were sequenced
•: A tumor suppressor gene, ELF3, was identified as a driver of ampullary carcinoma
•: ELF3 silencing in normal epithelial cells enhances their motility and invasion
•: Multi-region exome sequencing clarified clonal evolution in ampullary carcinoma

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