A Genetically Encoded Probe for Live-Cell Imaging of H4K20 Monomethylation

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A Genetically Encoded Probe for Live-Cell Imaging of H4K20 Monomethylation

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作者：Yuko Sato¹ ; ^{satoy@bio.titech.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Tomoya Kujirai² ; Ritsuko Arai³ ; ⁹ ; Haruhiko Asakawa⁴ ; Chizuru Ohtsuki⁴ ; Naoki Horikoshi² ; Kazuo Yamagata⁵ ; Jun Ueda⁶ ; Takahiro Nagase⁷ ; Tokuko Haraguchi⁴ ; ⁸ ; Yasushi Hiraoka⁴ ; ⁸ ; Akatsuki Kimura³ ; Hitoshi Kurumizaka² ; Hiroshi Kimura¹ ; ^{hkimura@bio.titech.ac.jp" class="auth_mail" title="E-mail the corresponding author}
关键词：H4K20me1 ; histone H4 Lys20 monomethylation ; Mintbody ; modification-specific intracellular antibody ; scFv ; single-chain variable fragment ; PCNA ; proliferating cell nuclear antigen ; FR ; framework region ; Xi ; inactive X chromosome
刊名：Journal of Molecular Biology
出版年：2016
出版时间：9 October 2016
年：2016
卷：428
期：20
页码：3885-3902
全文大小：1853 K

文摘

•: A histone H4K20me1-specific live-cell probe, H4K20me1-mintbody, was developed.
•: Dynamics and replication timing of Xi were visualized.
•: Critical amino acids for the stability and/or folding of the mintbody were revealed.

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