Exogenous supplement of N-acetylneuraminic acid ameliorates atherosclerosis in apolipoprotein E-deficient mice

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Exogenous supplement of N-acetylneuraminic acid ameliorates atherosclerosis in apolipoprotein E-deficient mice

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作者：Shoudong Guo ; ^{SD-GUO@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Hua Tian ; Rongrong Dong ; Nana Yang ; Ying Zhang ; Shutong Yao ; Yongjun Li ; Yawei Zhou ; Yanhong Si ; Shucun Qin
关键词：Cardiovascular disease ; Sialic acid ; Anti-Oxidation ; Anti-inflammation ; Reverse cholesterol transport ; Quercetin
刊名：Atherosclerosis
出版年：2016
出版时间：August 2016
年：2016
卷：251
期：Complete
页码：183-191
全文大小：2411 K

文摘

•: N-acetylneuraminic acid (NANA) decreased atherosclerotic plaque formation in apoE^−/− mice.
•: NANA dramatically reduced triglyceride via improving lipoprotein lipase activity.
•: NANA notably lowered plasma total cholesterol by up-regulating reverse cholesterol transport.
•: NANA notably decreased oxidative stress and inflammatory reaction.

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