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Orchiectomy reduces hepatotumorigenesis of H-ras12V transgenic mice via the MAPK pathway
详细信息
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作者:
Ai-Guo Wang
;
Hyung-
Bae
Moon
;
Sang-Young Chun
;
Tae-Hoon Lee
;
Dae
-
Yeul
Yu and Dong-Seok Lee
关键词:
Hepatotumorigenesis
;
Orchiectomy
;
Ovariectomy
;
Sex hormones
;
Transgenic mice
刊名:Life Sciences
出版年:2006
出版时间:19 October 2006
年:2006
卷:79
期:21
页码:1974-1980
全文大小:403 K
文摘
A common characteristic of hepatocellular carcinoma in humans and animals is a striking male prevalence. However, the underlying mechanisms remain largely unknown. We have reported that hepatotumorigenesis is prevalent in male H-
ras
12V transgenic mice (
Wang et al., 2005). Orchiectomy and ovariectomy were performed to determine if the presence of sex organ-related factors contributes to hepatotumorigenesis. After orchiectomy and ovariectomy, the mice were sampled at 6 months of age. The pathological diagnosis, sex hormone levels, expression of the H-
ras
12V transgene, and ras related signal pathways were determined. Orchiectomy significantly reduced the incidence of hepatotumorigenesis in males. However, no significant difference was detected in the incidence of tumorigenesis between ovariectomized and non-ovariectomized females. Molecular biochemical experiments showed that the sex organ-related factors significantly influenced transgene expression, which contributed to activation of the MAPK signaling pathway. The present study demonstrates that testis-related factors play important roles in hepatotumorigenesis in H-
ras
12V transgenic mice.
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