Amphipathic silica nanoparticles induce cytotoxicity through oxidative stress mediated and p53 dependent apoptosis pathway in human liver cell line HL-7702 and rat liver cell line BRL-3A

设为首页

收藏本站

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Readers' Guide

Opening Hours
Collections
Help Via Email

Publications

Electronic Information Resources

Amphipathic silica nanoparticles induce cytotoxicity through oxidative stress mediated and p53 dependent apoptosis pathway in human liver cell line HL-7702 and rat liver cell line BRL-3A

详细信息查看全文

作者：Daiying Zuo^a ; Zhenfang Duan^a ; Yuanyuan Jia^b ; Tianxue Chu^a ; Qiong He^a ; Juan Yuan^a ; Wei Dai^a ; Zengqiang Li^a ; Liguo Xing^b ; ^{liguo-xing@163.com" class="auth_mail" title="E-mail the corresponding author} ; Yingliang Wu^b ; ^{yingliang_wu@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Silica nanoparticles ; Hepatotoxicity ; Oxidative stress ; p53 ; Apoptosis
刊名：Colloids and Surfaces B: Biointerfaces
出版年：2016
出版时间：1 September 2016
年：2016
卷：145
期：Complete
页码：232-240
全文大小：1660 K

文摘

•: SiO₂ NPs dose-dependently induced cytotoxicity in HL-7702 and BRL-3A cells.
•: SiO₂ NPs induced cytotoxicity was through oxidative stress mediated and p53, caspase-3 and Bax/Bcl-2 dependent pathway.
•: HL-7702 cells were more sensitive to SiO₂ NPs induced cytotoxicity than BRL-3A cells.
•: Antioxidant vitamin C significantly attenuated SiO₂ NPs induced caspase-3 activation.