Enhanced Reconstitution of Human Erythropoiesis and Thrombopoiesis in an Immunodeficient Mouse Model with Kit<sup>Wv</sup> Mutations

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Enhanced Reconstitution of Human Erythropoiesis and Thrombopoiesis in an Immunodeficient Mouse Model with Kit^Wv Mutations

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作者：Ayano Yurino¹ ; Katsuto Takenaka² ; Takuji Yamauchi¹ ; Takuya Nunomura¹ ; Yasufumi Uehara¹ ; Fumiaki Jinnouchi¹ ; Kohta Miyawaki¹ ; Yoshikane Kikushige¹ ; Koji Kato¹ ; Toshihiro Miyamoto¹ ; Hiromi Iwasaki² ; Yuya Kunisaki² ; Koichi Akashi¹ ; ² ; ^{akashi@med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author}
刊名：Stem Cell Reports
出版年：2016
出版时间：13 September 2016
年：2016
卷：7
期：3
页码：425-438
全文大小：3503 K

文摘

•: Kit^Wv mutations in mice (BRGSK^Wv/Wv) promote human multi-lineage reconstitution
•: Robust human erythropoiesis and thrombopoiesis are reconstituted in BRGSK^Wv/Wv
•: Exogenous human cytokine is not required for multi-lineage engraftment in BRGSK^Wv/Wv
•: Kit^Wv mutations allow human HSPCs to outcompete mouse HSPCs in bone marrow niches

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