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Irinotecan and cisplatin with concurrent thoracic radiotherapy in a once-every-three-weeks schedule in patients with limited-disease small-cell lung cancer: A phase I study
文摘
Thirty-nine p atients with limited SCLC were enrolled onto this study. P atients received three courses of cispl atin 75 a0;mg/m 2 IV, d ay 1 and etoposide 100 a0;mg/m 2 IV, d ays 1–3 (EP regimen), followed by TRT (45–56 a0;Gy administered in 15 fr actions), and three courses of p aclit axel 175 a0;mg/m 2 IV, d ay 1 and cispl atin, as previously, on d ay 2 (PP regimen); cycles were repe ated every 21 d ays. ass=""h4"">ResultsAll patients were evaluable for toxicity and 34 for response. The overall response rate was 67 % (CR: 26 % ; PR: 41 % ; intention-to-treat analysis) (95 % CI: 53.0–84.2 % ). After a median follow-up period of 15 months, the median survival time was 15 months, the median time to tumor progression 8.3 months and the 1-year survival rate 53.8 % . Grade 3/4 neutropenia occurred in 39 % and 36 % of patients receiving EP and PP regimens, respectively. The incidence of febrile neutropenia was 5 % and 3 % for EP and PP regimens, respectively. Other hematologic and non-hematologic toxicities were mild, with the exception of esophagitis occuring in 36 % of patients during and/or immediately after radiotherapy. ass=""h4"">ConclusionConsolidation therapy with PP after sequential EP and thoracic radiotherapy is feasible and well-tolerated; however, the efficacy results are comparable with those previously obtained in the same patients’ population using a combination of EP and TRT. <a href=""http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T9C-4K18VJC-2-3&_cdi=5111&_user=10&_orig=article&_coverDate=07 % 2F31 % 2F2006&_sk=999469998&view=c&wchp=dGLbVlW-zSkWb&md5=c8a098eca09b1cce509a16bf64553f18&ie=/sdarticle.pdf"">ame=""pdf"" style=""vertical-align:absmiddle;"" border=""0"" src=""http://www.sciencedirect.com/scidirimg/icon_pdf.gif"" alt=""""> Purchase PDF (154 K)a> | able>ass=""infobubble-cont ainer""> ass=""mlktLink"" id=""mlktLink_2""> able cellpadding=0 cellspacing=0 border=0>align=""top"" style=""padding: 5px 5px 0px 5px"">are.gif"" alt=""""> | <a href=""/science?_ob=ArticleURL&_udi=B6T9C-4BD9TR1-2R&_user=10&_origUdi=B6T9C-4RHXT9P-1&_fmt=high&_coverDate=08 % 2F31 % 2F2003&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=4a32a28d0c8d4d77acb8ff398c3fa232"" onMouseOver=""InfoBubble.show('infobubble_2','mlktLink_2')"" onMouseOut=""InfoBubble.timeout()"">O-72 A pilot study of cisplatin and etoposide plus conc... Lung Cancera>
| able> ass=""infobubble"" id=""infobubble_2"" onMouseOver=""InfoBubble.show('infobubble_2','mlktLink_2')"" onMouseOut=""InfoBubble.timeout()""> able cellpadding=0 cellspacing=0 width=100 % >at:right; p adding-left:5px"">< a onclick=""InfoBubble.hide()""> alt=""Close"" title=""Close"" onmouseover=""j av ascript:this.src='/scidirimg/btn_xclose_hov.gif';"" onmouseout=""j av ascript:this.src='/scidirimg/btn_xclose.gif';""> a> alt=""You are not entitled to access the full text of this document"" title=""You are not entitled to access the full text of this document"" width=12 height=14""> <a href=""http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T9C-4BD9TR1-2R&_user=10&_coverDate=08 % 2F31 % 2F2003&_rdoc=1&_fmt=high&_orig=article&_cdi=5111&_sort=v&_docanchor=&view=c&_ct=761&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=5afa432a49f9448a0bda5631397bedd9"">O-72 A pilot study of cisplatin and etoposide plus concurrent accelerated hyperfractionated thoracic radiotherapy (TRT) followed by three cycles of irinotecan and cisplatin for the treatment of limited-stage small-cell lung cancer (SCLC): JCOG 9903-DIa> Lung Cancer,a0;Volume 41, Supplement 2,a0;August 2003, Page S24 Kaoru Kubota, Yutaka Nishiwaki, Takahiko Sugiura, Kazumasa Noda, Kiyoshi Mori, Masaaki Kawahara, Shunichi Negoro, Koshiro Watanabe, Tomohide Tamura, Nagahiro Saijo
<a href=""http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T9C-4BD9TR1-2R-1&_cdi=5111&_user=10&_orig=article&_coverDate=08 % 2F31 % 2F2003&_sk=999589999.8997&view=c&wchp=dGLbVlW-zSkWb&md5=96d329589da27fe2e6204ffa68a66b61&ie=/sdarticle.pdf"">ame=""pdf"" style=""vertical-align:absmiddle;"" border=""0"" src=""http://www.sciencedirect.com/scidirimg/icon_pdf.gif"" alt=""""> Purchase PDF (176 K)a> | able> ass=""infobubble-cont ainer""> ass=""mlktLink"" id=""mlktLink_3""> able cellpadding=0 cellspacing=0 border=0>align=""top"" style=""padding: 5px 5px 0px 5px"">are.gif"" alt=""""> | <a href=""/science?_ob=ArticleURL&_udi=B6T9C-4BD9TR1-FB&_user=10&_origUdi=B6T9C-4RHXT9P-1&_fmt=high&_coverDate=08 % 2F31 % 2F2003&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=fd930209f12344b7b9128738bccb55e6"" onMouseOver=""InfoBubble.show('infobubble_3','mlktLink_3')"" onMouseOut=""InfoBubble.timeout()"">P-58 Phase II study of irinotecan/cisplatin (IP) induct... Lung Cancera>
| able> ass=""infobubble"" id=""infobubble_3"" onMouseOver=""InfoBubble.show('infobubble_3','mlktLink_3')"" onMouseOut=""InfoBubble.timeout()""> able cellpadding=0 cellspacing=0 width=100 % >at:right; p adding-left:5px"">< a onclick=""InfoBubble.hide()""> alt=""Close"" title=""Close"" onmouseover=""j av ascript:this.src='/scidirimg/btn_xclose_hov.gif';"" onmouseout=""j av ascript:this.src='/scidirimg/btn_xclose.gif';""> a> alt=""You are not entitled to access the full text of this document"" title=""You are not entitled to access the full text of this document"" width=12 height=14""> <a href=""http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T9C-4BD9TR1-FB&_user=10&_coverDate=08 % 2F31 % 2F2003&_rdoc=1&_fmt=high&_orig=article&_cdi=5111&_sort=v&_docanchor=&view=c&_ct=761&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=24c8efa1704f32d57724b024e72f3af0"">P-58 Phase II study of irinotecan/cisplatin (IP) induction chemotherapy followed by concurrent twice-daily thoracic radiotherapy (RT) with etoposide/cisplatin (EP) for limited disease small cell lung cancer (LD-SCLC)a> Lung Cancer,a0;Volume 41, Supplement 2,a0;August 2003, Page S105 Ji-Youn Han, Kwan Ho Cho, Dae Ho Lee, Seong Min Yoon, Hyae Young Kim, Sung Young Lee, Han Jin Yoo, Jin Soo Lee
<a href=""http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T9C-4BD9TR1-FB-1&_cdi=5111&_user=10&_orig=article&_coverDate=08 % 2F31 % 2F2003&_sk=999589999.8997&view=c&wchp=dGLbVlW-zSkWb&md5=f6191d64db9b2a3e94dfd8811acfc6bc&ie=/sdarticle.pdf"">ame=""pdf"" style=""vertical-align:absmiddle;"" border=""0"" src=""http://www.sciencedirect.com/scidirimg/icon_pdf.gif"" alt=""""> Purchase PDF (176 K)a> | able> | ashed #CCCCCC; border-bottom: 1px solid #CCCCCC;background-color: #F6F6F6"" width=340>able cellpadding=0 cellspacing=0 width=""100 % "">align=""top"" style=""padding:3px 5px 0px 5px"">ang.gif"" alt=""""> | <a href=""/science?_ob=RelatedArtURL&_udi=B6T9C-4RHXT9P-1&_orig=article&_acct=C000050221&_version=1&_userid=10&md5=aa52f3cbf4ca7159e156b9477eb04ac6"">View More Related Articlesa> | able> | ass=""nojs"">argin: 0px; text-align: center"" onclick=""toggleMLKT('B6T9C-4RHXT9P-1','/scidirimg/btn_arrow_up_off.gif','/scidirimg/btn_arrow_down_off.gif','http://www.sciencedirect.com/science')"">arrow_up_off.gif"" id=""mlktArrow"" alt="""" border=""0"" onmouseover=""mlktHover(1,'/scidirimg/sci_dir/')"" onmouseout=""mlktHover(0,'/scidirimg/')""> | able> | align=""right"">abBoxContent""> | able>articleBody"" cl ass=""font3""> ass="" articleHe aderInner"" id="" articleHe ader""> ar.gif"" width=""1"" height=""10"" border=""0"" alt="""">< a href=""http://dx.doi.org/10.1016/j.lungc an.2007.11.010"" t arget=""doilink"" onClick=""v ar doiWin; doiWin=window.open('http://dx.doi.org/10.1016/j.lungc an.2007.11.010','doilink','scrollb ars=yes,resiz able=yes,directories=yes,toolb ar=yes,menub ar=yes,st atus=yes'); doiWin.focus()"">doi:10.1016/j.lungc an.2007.11.010 a> < a href = ""/science?_ob=HelpURL&_file=doi.htm&_ acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5= a143 a86ddc585c54 adbe80b2046626c3"" t arget=""sdhelp"" onMouseOver = ""window.st atus='Help is Av ail able';return true"" onClick=""v ar helpWin; helpWin=window.open('/science?_ob=HelpURL&_file=doi.htm&_ acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5= a143 a86ddc585c54 adbe80b2046626c3','sdhelp','scrollb ars=yes,resiz able=yes,directories=no,toolb ar=no,menub ar=no,st atus=no,width=760,height=570'); helpWin.focus()""> alt=""How to Cite or Link Using DOI (Opens New Window)"" title=""How to Cite or Link Using DOI (Opens New Window)"" border=""0"" align="" absmiddle""> a> Copyright a9; 2007 Elsevier Irel and Ltd All rights reserved. ass=""h4"">Short communication ass="" articleTitle""> Irinotecan and cisplatin with concurrent thoracic radiotherapy in a once-every-three-weeks schedule in patients with limited-disease small-cell lung cancer: A phase I study<a name=""bafn1"">a><a href=""http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T9C-4RHXT9P-1&_user=10&_coverDate=07 % 2F31 % 2F2008&_rdoc=19&_fmt=full&_orig=browse&_srch=doc-info( % 23toc % 235111 % 232008 % 23999389998 % 23693269 % 23FLA % 23display % 23Volume)&_cdi=5111&_sort=d&_docanchor=&_ct=22&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=fb7c3a28e305d364c64cae62bd063bfb#afn1"">alt=""star, open"" title=""star, open"" border=""0"">a>
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