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ass=""articleHeaderInner"" id=""articleHeader"">ar.gif"" width=""1"" height=""10"" border=""0"" alt=""""><a href=""http://dx.doi.org/10.1016/j.lungcan.2007.11.010"" target=""doilink"" onClick=""var doiWin; doiWin=window.open('http://dx.doi.org/10.1016/j.lungcan.2007.11.010','doilink','scrollbars=yes,resizable=yes,directories=yes,toolbar=yes,menubar=yes,status=yes'); doiWin.focus()"">doi:10.1016/j.lungcan.2007.11.010a> <a href = ""/science?_ob=HelpURL&_file=doi.htm&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a143a86ddc585c54adbe80b2046626c3"" target=""sdhelp"" onMouseOver = ""window.status='Help is Available';return true"" onClick=""var helpWin; helpWin=window.open('/science?_ob=HelpURL&_file=doi.htm&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a143a86ddc585c54adbe80b2046626c3','sdhelp','scrollbars=yes,resizable=yes,directories=no,toolbar=no,menubar=no,status=no,width=760,height=570'); helpWin.focus()"">alt=""How to Cite or Link Using DOI (Opens New Window)"" title=""How to Cite or Link Using DOI (Opens New Window)"" border=""0"" align=""absmiddle"">a>
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ass=""h4"">Short communication

ass=""articleTitle"">

Irinotecan and cisplatin with concurrent thoracic radiotherapy in a once-every-three-weeks schedule in patients with limited-disease small-cell lung cancer: A phase I study<a name=""bafn1"">a><a href=""http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T9C-4RHXT9P-1&_user=10&_coverDate=07 % 2F31 % 2F2008&_rdoc=19&_fmt=full&_orig=browse&_srch=doc-info( % 23toc % 235111 % 232008 % 23999389998 % 23693269 % 23FLA % 23display % 23Volume)&_cdi=5111&_sort=d&_docanchor=&_ct=22&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=fb7c3a28e305d364c64cae62bd063bfb#afn1"">alt=""star, open"" title=""star, open"" border=""0"">a>

Irinotecan and cisplatin with concurrent thoracic radiotherapy in a once-every-three-weeks schedule in patients with limited-disease small-cell lung cancer: A phase I study
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文摘
Thirty-nine patients with limited SCLC were enrolled onto this study. Patients received three courses of cisplatin 75&#xa0;mg/m2 IV, day 1 and etoposide 100&#xa0;mg/m2 IV, days 1–3 (EP regimen), followed by TRT (45–56&#xa0;Gy administered in 15 fractions), and three courses of paclitaxel 175&#xa0;mg/m2 IV, day 1 and cisplatin, as previously, on day 2 (PP regimen); cycles were repeated every 21 days.

ass=""h4"">Results

All patients were evaluable for toxicity and 34 for response. The overall response rate was 67 % (CR: 26 % ; PR: 41 % ; intention-to-treat analysis) (95 % CI: 53.0–84.2 % ). After a median follow-up period of 15 months, the median survival time was 15 months, the median time to tumor progression 8.3 months and the 1-year survival rate 53.8 % . Grade 3/4 neutropenia occurred in 39 % and 36 % of patients receiving EP and PP regimens, respectively. The incidence of febrile neutropenia was 5 % and 3 % for EP and PP regimens, respectively. Other hematologic and non-hematologic toxicities were mild, with the exception of esophagitis occuring in 36 % of patients during and/or immediately after radiotherapy.

ass=""h4"">Conclusion

Consolidation therapy with PP after sequential EP and thoracic radiotherapy is feasible and well-tolerated; however, the efficacy results are comparable with those previously obtained in the same patients’ population using a combination of EP and TRT.


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