Oleanolic acid ameliorates cognitive dysfunction caused by cholinergic blockade via TrkB-dependent BDNF signaling

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• 作者：Se Jin Jeon^a ; Hong Ju Lee^c ; Hyung Eun Lee^a ; Se Jin Park^a ; Yubeen Gwon^a ; Haneul Kim^a ; Jiabao Zhang^a ; Chan Young Shin^e ; Dong Hyun Kim^c ; ^d ; ^{mose79@dau.ac.kr} ; Jong Hoon Ryu^a ; ^b ; ^{jhryu63@khu.ac.kr}
• 关键词：Oleanolic acid ; Memory improvement ; Scopolamine model ; BDNF signaling ; TrkB
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：100-109
• 全文大小：868 K
• 卷排序：113

文摘

Oleanolic acid activated the ERK1/2-CREB-BDNF pathway in the hippocampus via TrkB activation. Scopolamine-induced memory dysfunction was ameliorated by oleanolic acid treatment. Oleanolic acid evoked the long-term potentiation in a dose-dependent manner. Oleanolic acid would be a potential therapeutic agent for the cognitive problem.