Quercetin induces autophagy via FOXO1-dependent pathways and autophagy suppression enhances quercetin-induced apoptosis in PASMCs in hypoxia

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• 作者：Yuanzhou He ; Xiaopei Cao ; Pujian Guo ; Xiaochen Li ; Huihui Shang ; Jin Liu ; Min Xie ; Yongjian Xu ; Xiansheng Liu ; ^{doctorliu69@126.com}
• 关键词：PAH ; pulmonary arterial hypertension ; PASMCs ; pulmonary arterial smooth muscle cells ; FOXO1 ; forkhead box proteins 1 ; RVSP ; right ventricular systolic pressure
• 刊名：Free Radical Biology and Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：103
• 期：Complete
• 页码：165-176
• 全文大小：2743 K
• 卷排序：103

文摘

Quercetin induce the apoptotic and autophagic capacities of cells in hypoxia. Quercetin enhance hypoxia-induced autophagy through the FOXO1-SENS3-mTOR pathway. Treatment with autophagy-specific inhibitors enhance quercetin-induced apoptosis.