Activation of the cholinergic anti-inflammatory pathway by nicotine ameliorates lipopolysaccharide-induced preeclampsia-like symptoms in pregnant rats

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• 作者：Yuanyuan Liu ; Jinying Yang ; Junjie Bao ; Xiaolan Li ; Aihua Ye ; Guozheng Zhang ; Huishu Liu ; ^{huishuliu@hotmail.com}
• 关键词：Preeclampsia ; Inflammation ; Nicotine ; α7nAChR ; NF-κB
• 刊名：Placenta
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：49
• 期：Complete
• 页码：23-32
• 全文大小：2969 K
• 卷排序：49

文摘

Nicotine decreased high SBP, urinary protein excretion and the levels of cytokines in the LPS-induced PE rats. Nicotine increased the expression of α7nAChR and attenuated the activation of NF-κB p65 in the placenta. The cholinergic antagonist α-bungarotoxin reversed the protective effects of nicotine in preeclampsia rats. Nicotine ameliorates LPS-induced preeclampsia-like symptoms in pregnant rats may through α7nAChR.