Tachykinin NK₁ and NK₂ receptors mediate non-adrenergic non-cholinergic excitatory neuromuscular transmission in the guinea-pig stomach

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• 作者：Zagorodnyuk ; V. ; Maggi ; C. A.
• 关键词：guinea-pig stomach ; NANC excitatory junction potentials ; tachykinins ; tachykinin receptors
• 刊名：Neuroscience
• 出版年：1997
• 出版时间：September, 1997
• 年：1997
• 卷：80
• 期：2
• 页码：625-634
• 全文大小：848 K

文摘

By using selective tachykinin NK₁ and NK₂ receptor antagonists and agonists, we studied the excitatory non-adrenergic non-cholinergic transmission to the circular muscle of the corpus of guinea-pig stomach by the sucrose-gap method. After elimination of inhibitory junction potentials by apamin (0.1 μM), l-nitroarginine (30 μM) and tetraethylammonium (10 mM), electrical field stimulation (10 Hz) in the presence of atropine (1 μM) and nifedipine (1 μM) evoked a pure excitatory junction potential and contraction. The selective tachykinin NK₂ receptor antagonist, MEN 11420, concentration-dependently inhibited the non-adrenergic non-cholinergic excitatory junction potential (EC₅₀