Zebrafish STAT6 negatively regulates IFNφ1 production by attenuating the kinase activity of TANK-binding kinase 1

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• 作者：Shun Li^a ; Long-Feng Lu^a ; ^b ; Scott E. LaPatra^c ; Dan-Dan Chen^a ; Yong-An Zhang^a ; ^{yzhang@ihb.ac.cn}
• 关键词：STAT6 ; Negative regulator ; Interferon ; TBK1 ; Zebrafish
• 刊名：Developmental & Comparative Immunology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：67
• 期：Complete
• 页码：189-201
• 全文大小：2210 K
• 卷排序：67

文摘

Zebrafish STAT6 interacts with MITA and TBK1. Zebrafish STAT6 decreases the kinase activity of TBK1. Zebrafish STAT6 negatively regulates TBK1-mediated activation of IFNφ1. Zebrafish STAT6 facilitates virus replication by suppression of IFNφ1.