GAPDH-mediated posttranscriptional regulations of sodium channel Scn1a and Scn3a genes under seizure and ketogenic diet conditions

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• 作者：Guo-Wang Lin¹ ; Ping Lu¹ ; Tao Zeng ; Hui-Ling Tang ; Yong-Hong Chen ; Shu-Jing Liu ; Mei-Mei Gao ; Qi-Hua Zhao ; Yong-Hong Yi ; Yue-Sheng Long ; ^{longyuesheng@gzhmu.edu.cn}
• 关键词：Glyceraldehyde-3-phosphate dehydrogenase ; Sodium channel ; Seizure ; Ketogenic diet ; Posttranscriptional regulation
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：480-489
• 全文大小：1466 K
• 卷排序：113

文摘

GAPDH binds to a conserved region in the 3′ UTRs of SCN1A and SCN3A genes. The binding of GAPDH to the conserved element alters gene expression. GAPDH mediates abnormal expressions of Scn1a and Scn3a under seizure condition. KD or BHB treament rescues abnormal expressions of Scn1a and Scn3a via GADPH.