Flavans with potential anti-inflammatory activities from Zephyranthes candida

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• 作者：Guanqun Zhan^a ; Junfei Zhou^a ; Tingting Liu^a ; Guijuan Zheng^a ; Haji Akber Aisa^b ; Guangmin Yao^a ; ^{gyap@mail.hust.edu.cn}
• 关键词：Zephyranthes candida ; Flavans ; Anti-inflammatory activities ; Amaryllidacea
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：26
• 期：24
• 页码：5967-5970
• 全文大小：665 K
• 卷排序：26

文摘

Three new flavans, (2R,3R)-7-methoxy-flavan-3-ol (1), (2S)-7,3′-dihydroxy-4′-methoxyflavan 3′-O-β-d-glucopyranoside (2), (2S)-7,3′-dihydroxy-4′-methoxyflavan 7-O-β-d-glucopyranoside (3), and one known flavan (4) were isolated from the whole plants of Zephyranthes candida (Amaryllidacea). The structures of the new flavans 1–3 were determined by extensive spectroscopic analyses including HRESIMS, NMR, and electronic circular dichroism (ECD), and the absolute configuration of 1 was confirmed by single-crystal X-ray diffraction analysis with Cu Kα irradiation. Flavans 1–3 displayed significant inhibitory effects on the LPS-induced NO production in RAW264.7 mouse macrophages with IC50 values of 17.34, 16.14, and 21.52 μM, respectively, suggesting their potentials for anti-inflammatory agents.