Human amniotic epithelial cells inhibit CD4+ T cell activation in acute kidney injury patients by influencing the miR-101-c-Rel-IL-2 pathway

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• 作者：Junfeng Liu^a ; ¹ ; Rong Hua^b ; ¹ ; Zhangbin Gong^c ; ¹ ; Bin Shang^f ; Yongyi Huang^g ; Lihe Guo^h ; Te Liu^d ; ^e ; ^{te.liu@yale.edu} ; Jun Xue^a ; ^{xuejun@fudan.edu.cn}
• 关键词：Human amniotic epithelial cells (HuAECs) ; Acute kidney injury (AKI) ; CD4+ T ; MicroRNA-101 (miR-101) ; c-Rel ; IL-2
• 刊名：Molecular Immunology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：81
• 期：Complete
• 页码：76-84
• 全文大小：2505 K
• 卷排序：81

文摘

HuAECs reduced proliferation rate of patient-derived CD4+ T cells. HuAECs reduced IL-2 released from patient-derived CD4+ T cells. Overexpressed miR-101 reduced expression c-Rel and IL-2 in AKI patient-derived CD4+ T cells. Overexpressed miR-101 decreased binding capacities of ‘c-Rel-NFκB’ complex on IL-2 promoter. HuAECs stimulate miR-101 expression to inhibit AKI patient-derived CD4+ T cells activation.