Dioscin protects against ANIT-induced cholestasis via regulating Oatps, Mrp2 and Bsep expression in rats

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Dioscin protects against ANIT-induced cholestasis via regulating Oatps, Mrp2 and Bsep expression in rats

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作者：Aijie zhang^a ; ^c ; ^{zhangaijie1986@163.com" class="auth_mail" title="E-mail the corresponding author} ; Yongming Jia^a ; ^{yongmingjiahlj@126.com" class="auth_mail" title="E-mail the corresponding author} ; Qinghan Xu^a ; ^{xulianglinyao@126.com" class="auth_mail" title="E-mail the corresponding author} ; Changyuan Wang^a ; ^b ; ^{wangcyuan@163.com" class="auth_mail" title="E-mail the corresponding author} ; Qi Liu^a ; ^b ; ^{llaqii@yahoo.com.cn" class="auth_mail" title="E-mail the corresponding author} ; Qiang Meng^a ; ^b ; ^{mengq531@yahoo.cn" class="auth_mail" title="E-mail the corresponding author} ; Jinyong Peng^a ; ^b ; ^{jinyongpeng2005@163.com" class="auth_mail" title="E-mail the corresponding author} ; Huijun Sun^a ; ^b ; ^{sunhuijun@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Pengyuan Sun^a ; ^{spfar1004@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Xiaokui Huo^a ; ^b ; ^{huoxiaokui@163.com" class="auth_mail" title="E-mail the corresponding author} ; Kexin Liu^a ; ^b ; ^{kexinliu@dlmedu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：ALT ; alanine amiotransferase ; ANIT ; alpha-naphthylisothiocyanate ; AST ; aspartate transaminase ; BIL ; bilirubin ; Bsep ; bile salt export pump ; CMC-Na ; carboxymethylcellulose sodium ; E3S ; estrone-3-sulfate ; FXR ; Farnesoid X receptor ; IS ; hydrochlorothiazide ; LC-MS/MS ; liquid chromatography-tandem mass spectrometry ; Mrp ; multidrug resistance-associated protein ; Ntcp ; Na+-taurocholate cotransporting polypeptide ; Oatp ; organic anion transporting polypeptide ; qRT-PCR ; Quantitive Real Time-polymerase cha
刊名：Toxicology and Applied Pharmacology
出版年：2016
出版时间：15 August 2016
年：2016
卷：305
期：Complete
页码：127-135
全文大小：1757 K

文摘

•: Cholestasis was improved by dioscin via up-regulating the expression of Oatps, Mrp2 and Bsep.
•: Dioscin regulated Mrp2 and Bsep via activating FXR.
•: Dioscin may be a candidate drug for the prevention of intrahepatic cholestasis.