Synthetic Toll-like receptor 7 ligand inhibits porcine reproductive and respiratory syndrome virus infection in primary porcine alveolar macrophages

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Synthetic Toll-like receptor 7 ligand inhibits porcine reproductive and respiratory syndrome virus infection in primary porcine alveolar macrophages

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作者：Yongkun Du^a ; ^b ; ¹ ; ^{mututushen@163.com" class="auth_mail" title="E-mail the corresponding author} ; Taofeng Du^a ; ^b ; ¹ ; ^{taofengdu@nwsuaf.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Yunpeng Shi^a ; ^b ; ^{ling.dongyi@163.com" class="auth_mail" title="E-mail the corresponding author} ; Angke Zhang^a ; ^b ; ^{zhangangke1112@126.com" class="auth_mail" title="E-mail the corresponding author} ; Chong Zhang^a ; ^b ; ^{leofighting@163.com" class="auth_mail" title="E-mail the corresponding author} ; Yuwen Diao^c ; ^d ; ^{diaoyuwen@szu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Guangyi Jin^c ; ^d ; ^{gyjin@szu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; En-Min Zhou^a ; ^b ; ^{zhouem@nwsuaf.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：PRRSV ; TLR7 ; Antivirus factor ; ISGs ; NF-κB
刊名：Antiviral Research
出版年：2016
出版时间：July 2016
年：2016
卷：131
期：Complete
页码：9-18
全文大小：2867 K

文摘

•: TLR7 ligand (SZU101) prevents PRRSV replication in PAMs.
•: SZU101 treatment activates NF-κB and induces antiviral cytokines and genes expression.
•: Blocking the activation of NF-κB reverses the suppression effect of SZU101 on PRRSV replication.
•: Inhibiting the proper subcellular localization of TLR7 using specific inhibitor reverses the anti-PRRSV effect of SZU101.
•: Co-administration of SZU101 and PRRSV enhances the humoral and cellular immune responses against PRRSV antigens in mice.

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