Natural and unnatural anthraquinones isolated from the ethanol extract of the roots of Knoxia valerianoides

详细信息    查看全文

• 作者：Feng Zhao ; Sujuan Wang ; Sheng Lin ; Chenggen Zhu ; Zhenggang Yue ; Yang Yu ; Bo Liu ; Xiuli Wu ; Yongchun Yang ; Yan Li ; Jiangong Shi ; ^{shijg@imm.ac.cn}
• 关键词：Knoxia valerianoides ; Rubiaceae ; Anthraquinone ; Solvolytic artifacts ; HPLC&ndash ; DAD&ndash ; ESI&ndash ; MS analysis ; Hepatocyte (WB-F344) damage protection
• 刊名：Acta Pharmaceutica Sinica B
• 出版年：2012
• 出版时间：June, 2012
• 年：2012
• 卷：2
• 期：3
• 页码：260-266
• 全文大小：363 K

文摘

Eight new 9,10-anthraquinones (1-8) including three acetonide derivatives of 3-hydroxy-2-hydroxymethyl-9,10-anthraquinones (6-8) were isolated from an ethanol extract of the roots of Knoxia valerianoides. On the basis of chemical transformation reactions of the co-occurring 14 and 15 combined with HPLC-DAD-ESI-MS analysis of the extracts, the previously and newly isolated 2-methoxymethyl- and 2-ethoxymethyl-9,10-anthraquinones (4, 5, and 9-13), as well as the 3-hydroxy-2-hydroxymethyl-9,10-anthraquinone acetonide derivatives (6-8), were shown to be solvolytic artifacts. In the in vitro assays, compound 4 was active to protect hepatocyte (WB-F344) damage.