Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK

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• 作者：Ming Wang ; Chenglong Li ; Hui Nie ; Xin Lv ; Ying Qu ; Beiqin Yu ; Liping Su ; Jianfang Li ; Xuehua Chen ; Jingfang Ju ; Yingyan Yu ; Min Yan ; Qinlong Gu ; Zhenggang Zhu ; Bingya Liu
• 关键词：miRNA ; Invasion ; ILK ; Metastasis ; Gastric cancer ; miR-625
• 刊名：FEBS Letters
• 出版年：2012
• 出版时间：30 July, 2012
• 年：2012
• 卷：586
• 期：16
• 页码：2382-2388
• 全文大小：1184 K

文摘

Accumulating evidence has shown that microRNAs are involved in multiple processes in cancer development and progression. Here, we report that expression of miR-625 is significantly down-regulated and negatively correlated with lymph node metastasis in gastric cancer. miR-625 significantly inhibits invasion and metastasis of gastric cancer cells both in vitro and in vivo. Moreover, we identify that ILK is a direct target gene for miR-625 and knockdown of ILK has a phenocopy of overexpression of miR-625. Taken together, our findings suggest that miR-625 plays an important role in the mechanism of tumor metastasis.