A d-f heteronuclear complex for dual-mode phosphorescence and magnetic resonance imaging

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• 作者：Hong Yang ; Liang Ding ; Lu An ; Zheyuan Xiang ; Min Chen ; Jing Zhou ; Fuyou Li ; Dongmei Wu ; Shiping Yang
• 关键词：d-f heteronuclear complex ; Ir&ndash ; Gd complex ; Phosphorescence imaging ; Magnetic resonance imaging
• 刊名：Biomaterials
• 出版年：2012
• 出版时间：November, 2012
• 年：2012
• 卷：33
• 期：33
• 页码：8591-8599
• 全文大小：2129 K

文摘

A d-f heteronuclear complex (Ir-Gd) by coupling an iridium(III) complex to a macrocycle-based gadolinium complex has been developed as as a dual-mode bioimaging probe for luminescence imaging and magnetic resonance imaging (MRI). The cyclometalated iridium complex showed an intense visible metal-to-ligand charge transfer (MLCT) absorption and strong yellow phosphorescent luminescence. It has specificity of staining in murine mitochondria confirmed by confocal laser scanning microscopy. The macrocycle-based gadolinium complex provides the longitudinal relaxivity of 3.36?mm^?1s^?1 on a 3 T system, which has been applied to MRI for liver in mice. Furthermore, the biodistribution of Ir-Gd has been investigated using inductively coupled plasma-atomic emission spectroscopy (ICP-AES) analyses. Such platform should be extended to further applications in the identification and diagnosis of liver diseases.