RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells

详细信息    查看全文

• 作者：Honglian Zhang¹ ; ⁵ ; Haiyun Gan¹ ; ⁵ ; Zhiquan Wang² ; ⁵ ; Jeong-Heon Lee² ; Hui Zhou¹ ; Tamas Ordog² ; Marc S. Wold³ ; Mats Ljungman⁴ ; Zhiguo Zhang¹ ; ⁶ ; ^{zz2401@cumc.columbia.edu}
• 关键词：RPA ; H3.3 deposition ; HIRA ; enhancer ; histone chaperone ; promoter ; R-loop ; nucleosome assembly
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：19 January 2017
• 年：2017
• 卷：65
• 期：2
• 页码：272-284
• 全文大小：4206 K
• 卷排序：65

文摘

RPA regulates the deposition of newly synthesized H3.3 independent of the cell cycle RPA interacts with HIRA directly and forms a RPA-HIRA-H3.3 complex RPA co-localizes with HIRA and H3.3 at gene regulatory elements RPA and HIRA regulate transcriptional directionality at promoters