Treatment of cholestatic fibrosis by altering gene expression of Cthrc1: Implications for autoimmune and non-autoimmune liver disease

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Treatment of cholestatic fibrosis by altering gene expression of Cthrc1: Implications for autoimmune and non-autoimmune liver disease

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作者：Zhaolian Bian^a ; ¹ ; ^{bianzhaolian1998@163.com" class="auth_mail" title="E-mail the corresponding author} ; Qi Miao^a ; ¹ ; ^{miaoqi0730@126.com" class="auth_mail" title="E-mail the corresponding author} ; Wei Zhong^a ; ¹ ; ^{rjzhongwei@163.com" class="auth_mail" title="E-mail the corresponding author} ; Haiyan Zhang^a ; ^{heidi0509@163.com" class="auth_mail" title="E-mail the corresponding author} ; Qixia Wang^a ; ^{wqx0221155@126.com" class="auth_mail" title="E-mail the corresponding author} ; Yanshen Peng^a ; ^{pengyanshen@yahoo.com.cn" class="auth_mail" title="E-mail the corresponding author} ; Xiaoyu Chen^a ; ^{1621508481@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Canjie Guo^a ; ^{guocanjie@yahoo.com.cn" class="auth_mail" title="E-mail the corresponding author} ; Li Shen^a ; ^{shirleypear@126.com" class="auth_mail" title="E-mail the corresponding author} ; Fan Yang^a ; ^{flyingfish_yf@163.com" class="auth_mail" title="E-mail the corresponding author} ; Jie Xu^a ; ^{jiexu@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Dekai Qiu^a ; ^{qiudekai2008@126.com" class="auth_mail" title="E-mail the corresponding author} ; Jingyuan Fang^a ; ^{fangjingyuan_new@163.com" class="auth_mail" title="E-mail the corresponding author} ; Scott Friedman^b ; ^{scott.friedman@mssm.edu" class="auth_mail" title="E-mail the corresponding author} ; Ruqi Tang^a ; ^{ruqi_tang@126.com" class="auth_mail" title="E-mail the corresponding author} ; ^{ruqi.tang@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; M. Eric Gershwin^c ; ^{megershwin@ucdavis.edu" class="auth_mail" title="E-mail the corresponding author} ; Xiong Ma^a ; ^{maxiongmd@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Hepatic fibrosis ; Cholestatic liver fibrosis ; Hepatic stellate cell ; Anti-fibrotic treatment ; TGF-尾 pathway
刊名：Journal of Autoimmunity
出版年：2015
出版时间：September 2015
年：2015
卷：63
期：Complete
页码：76-87
全文大小：4139 K

文摘

•: A major unmet need in autoimmunity and cholestatic liver disease is the prevention and treatment of fibrosis.
•: Knocking in/knockout out the Cthrc1 gene significantly modulates cholestatic fibrosis in two murine models.
•: The mechanism of Cthrc1 gene expression and its effect on fibrosis is by TGF-尾1 via phospho-Smad3 binding.
•: Cthrc1 inhibits TGF-尾 signaling through a proteosomal pathway.
•: Use of truncated fragments of Cthrc1 may serve as a model to further understand fibrosis, but also as a therapeutic tool.