MicroRNA-106b in cancer-associated fibroblasts from gastric cancer promotes cell migration and invasion by targeting PTEN

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MicroRNA-106b in cancer-associated fibroblasts from gastric cancer promotes cell migration and invasion by targeting PTEN

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作者：Ting-Song Yang¹ ; ^{surgeonyts@163.com" class="auth_mail} ; Xiao-Hu Yang¹ ; ^{shuaitiger@163.com" class="auth_mail} ; Xi Chen¹ ; ^{beautycici@163.com" class="auth_mail} ; Xu-Dong Wang ^{wxd19831208@163.com" class="auth_mail} ; Jie Hua ^{surgeonhuajie@hotmail.com" class="auth_mail} ; Dong-Lei Zhou ^{surgeonytszdl@hotmail.com" class="auth_mail} ; Bo Zhou ^{surgeonzhoubo@163.com" class="auth_mail} ; Zhen-Shun Song ; ^{songzhenshun@hotmail.com" class="auth_mail}
关键词：CAFs ; cancer associated fibroblasts ; NFs ; normal fibroblasts ; miRNA ; microRNA ; PTEN ; protein tyrosine phosphatase and tensin homologue ; 伪-SMA ; 伪-smooth muscle actin ; FSP1 ; fibroblast specific protein 1 ; FAP ; fibroblast activation protein ; TGF-尾 ; transforming growth factor-尾 ; HGF ; hepatocyte growth factor ; PDGF ; platelet-derived growth factor ; FGF-7 ; fibroblast growth factor-7 ; SDF-1 ; stromal cell-derived factor-1
刊名：FEBS Letters
出版年：13 June 2014
年：2014
卷：588
期：13
页码：2162-2169
全文大小：1829 K

文摘

•: MiR-106b is up-regulated in CAFs compared to NFs in gastric cancer.
•: Down-regulation of miR-106b in CAFs inhibits cancer cell motility by targeting PTEN.
•: MiR-106b might be a potential therapeutic target for gastric cancer.

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