Structural insights into the function of steroidogenic cytochrome P450 17A1

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• 作者：Rahul Yadav ; Elyse M. Petrunak¹ ; D. Fernando Estrada² ; Emily E. Scott ; ^{eescott@ku.edu}
• 关键词：Steroidogenesis ; Cytochrome P450 17A1 ; X-ray crystallography ; 17α&minus ; hydroxylase ; 17 ; 20-Lyase
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：441
• 期：Complete
• 页码：68-75
• 全文大小：1879 K
• 卷排序：441

文摘

CYP17A1 structures with steroidal substrates and inhibitors are reviewed. Structures suggest subtle control of substrate positioning above the heme iron. Cytochrome b5 allosterically alters the conformation of the CYP17A1 active site roof.