Regio- and stereoselective reduction of 17-oxosteroids to 17β-hydroxysteroids by a yeast strain Zygowilliopsis sp. WY7905

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• 作者：Yuanyuan Liu^a ; ^b ; ¹ ; Yu Wang^b ; ¹ ; Xi Chen^b ; Qiaqing Wu^b ; ^{wu_qq@tib.cas.cn} ; Min Wang^a ; Dunming Zhu^b ; ^{zhu_dm@tib.cas.cn} ; Yanhe Ma^b
• 关键词：TS ; testosterone ; AD ; 4-androstene-3 ; 17-dione ; HSD ; hydroxysteroid dehydrogenase ; ADD ; androst-1 ; 4-dien-3 ; 17-dione ; DHEA ; 3β-hydroxyandrost-5-en-17-one ; DMF ; N ; N-dimethylformamide ; DMSO ; dimethyl sulfoxide ; EA ; ethyl acetate ; MTBE ; methyl tertiary butyl ether
• 刊名：Steroids
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：118
• 期：Complete
• 页码：17-24
• 全文大小：2339 K
• 卷排序：118

文摘

Zygowilliopsis sp. WY7905 contained constitutive 17β-hydroxysteroid dehydrogenases. It effectively catalyzed the reduction of androst-4-ene-3,17-dione to testosterone. It also reduced other 17-oxosteroids to the corresponding 17β-hydroxysteroids. It was not active toward steroids with only C-3 or C-20 carbonyl groups.