Psoriatic inflammation causes hepatic inflammation with concomitant dysregulation in hepatic metabolism via IL-17A/IL-17 receptor signaling in a murine model

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• 作者：Naif O. Al-Harbi^a ; Ahmed Nadeem^a ; ^{anadeem@ksu.edu.sa} ; Mohammed M. Al-Harbi^a ; Khairy M.A. Zoheir^a ; Mushtaq A. Ansari^a ; Ahmed M. El-Sherbeeny^b ; Khalid M. Alanazi^c ; Moureq R. Alotaibi^a ; Sheikh F. Ahmad^a
• 关键词：IL-17RC ; IL-17 receptor C ; iNOS ; Inducible nitric oxide synthase ; NFκB ; Nuclear factor-kappa B ; IMQ ; Imiquimod
• 刊名：Immunobiology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：222
• 期：2
• 页码：128-136
• 全文大小：1432 K
• 卷排序：222

文摘

Psoriatic inflammation causes hepatic inflammation in mice. Psoriatic inflammation enhances hepatic IL-17RC/NFκB signaling. Psoriatic inflammation causes dysregulation of hepatic metabolism. IL-17A blockade reduces hepatic inflammation in psoriatic mice. rmIL-17A aggravates hepatic inflammation in psoriatic mice.