DNA/BSA binding ability and genotoxic effect of mono- and binuclear copper (II) complexes containing a Schiff base derived from salicylaldehyde and D, L-glutamic acid

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• 作者：Lucia Andrez&aacute ; lov&aacute ; ^a ; Jana Pl&scaron ; í ; kov&aacute ; ^b ; ^d ; Jana Janočkov&aacute ; ^b ; ^e ; Katarí ; na Koňarikov&aacute ; ^a ; Ingrid Žitňanov&aacute ; ^a ; M&aacute ; ria Kohú ; tov&aacute ; ^c ; M&aacute ; ria Kožurkov&aacute ; ^b ; ^e ; ^{maria.kozurkova@upjs.sk}
• 关键词：Cu(II) complexes ; Calf thymus DNA ; Bovine serum albumin ; Comet assay ; MCF-7 ; HEK-293T
• 刊名：Journal of Organometallic Chemistry
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：827
• 期：Complete
• 页码：67-77
• 全文大小：1239 K
• 卷排序：827

文摘

This study examined a two of Cu(II) complexes containing Schiff bases. The binding constants for complex-DNA were K = 8.9 and 3.1 × 103 M−1. The binding constants for complex-BSA were K = 2.74 × 105 and 2.54 × 106 M−1. Complexes 1 and 2 induced significant DNA damage in MCF-7 cancer cell lines. Healthy HEK-293T cell lines were more resistant against their effect.