Transfusion medicine in a developing country – Alloantibodies to red blood cells in multi-transfused patients in Saudi Arabia

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• 作者：Abdel Galil M. Abdel Gader ; Abeer K. Al Ghumlas ; Abdel Kareem M. Al-Momen
• 关键词：Alloimmunization ; Multiple transfusion ; Thalassaemia ; Sickle cell disease
• 刊名：Transfusion and Apheresis Science
• 出版年：2008
• 出版时间：December 2008
• 年：2008
• 卷：39
• 期：3
• 页码：199-204
• 全文大小：109 K

文摘

Background

Multiple transfusions are frequently complicated by alloimmunization. This retrospective study aims to determine whether alloimmunization could be accounted for by racial differences between donors and recipients.

Materials and methods

The development of alloantibodies were determined in 68 multi-transfused patients (thalassaemia, n = 38) and (sickle cell anemia, n = 30).

Results

The overall frequency of alloantibody formation in our patients is 22.06 % . Thirteen patients received blood from the same ethnic group (Arab) and none developed antibodies, while of 47 patients who received multi-ethnic blood, 10 developed alloantibodies.

Conclusions

Alloantibodies formation can be reduced by limiting the transfusion of RBC, collected from donors of the same ethnic origin.