N-brain natriuretic peptide: correlation with tricuspid insufficiency in Gaucher disease

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• 作者：Elstein ; Deborah ; Nir ; Amiram ; Klutstein ; Mark ; Abrahamov ; Aya ; Zimran ; Ari
• 关键词：Gaucher disease ; Pulmonary hypertension ; Brain natriuretic peptide ; Tricuspid insufficiency ; Enzyme replacement therapy
• 刊名：Pulmonary Pharmacology & Therapeutics
• 出版年：2004
• 出版时间：October, 2004
• 年：2004
• 卷：17
• 期：5
• 页码：319-323
• 全文大小：104 K

文摘

NT-pro-brain natriuretic peptide (NT-proBNP) values are correlated with right ventricle dysfunction in pulmonary hypertension and have been recommended as a prognostic marker for symptomatic primary pulmonary hypertension. The purpose of this pilot study was to determine whether NT-proBNP values correlate with mild to moderate pulmonary hypertension in Gaucher disease. The NT-proBNP assay was performed on sera from patients with type I (non-neuronopathic) Gaucher disease who were known to have tricuspid insufficiency (TI) gradient values on echocardiography that were normal (TI<20mmHg), borderline (TI=25–29mmHg), or abnormal (TI≥30mmHg) over time. There was a statistically significant correlation (p