The role of astrocytes in the hypothalamic response and adaptation to metabolic signals

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The role of astrocytes in the hypothalamic response and adaptation to metabolic signals

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作者：Julie A. Chowen^a ; ^{julieann.chowen@salud.madrid.org" class="auth_mail" title="E-mail the corresponding author} ; ^{jachowen@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Pilar Argente-Arizó ; n^a ; ^b ; Alejandra Freire-Regatillo^a ; ^b ; Laura M. Frago^a ; ^b ; Tamas L. Horvath^c ; Jesú ; s Argente^a ; ^b
关键词：ACBP ; acyl-CoA binding protein ; ACC ; acetyl-CoA carboxylase ; AgRP ; agouti-related protein ; ALKO ; astrocytic leptin-receptor knockout ; AMPK ; AMP-activated kinase ; ApoE ; apolipoprotein E ; AR ; androgen receptor ; BBB ; blood brain barrier ; CART ; cocaine-and-amphetamine-regulated transcript ; CB1 ; cannabinoid receptor 1 ; DMH ; dorsal-medial hypothalamus ; DBI ; diazepam-binding inhibitor ; DAG ; diacylglycerol ; DIO ; diet-induced obesity ; DR ; diet-resistant ; ER ; estrogen receptor ; GABA ; gamma-amino-butyric a
刊名：Progress in Neurobiology
出版年：2016
出版时间：September 2016
年：2016
卷：144
期：Complete
页码：68-87
全文大小：2518 K

文摘

•: Hypothalamic astrocytes mediate metabolic effects on the melanocortin circuit.
•: High fat diets and obesity modulate astrocyte morphology and function.
•: Leptin targets hypothalamic astrocytes.
•: Astrocytes participate in glucose and fatty acid sensing to modulate systemic metabolism.

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