Acetylation of histones in neocortex and hippocampus of rats exposed to different modes of hypobaric hypoxia: Implications for brain hypoxic injury and tolerance

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Acetylation of histones in neocortex and hippocampus of rats exposed to different modes of hypobaric hypoxia: Implications for brain hypoxic injury and tolerance

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作者：Mikhail Samoilov^a ; Anna Churilova^a ; Tatjana Gluschenko^a ; Oleg Vetrovoy^a ; ^d ; Natalia Dyuzhikova^c ; Elena Rybnikova^b ; ^{rybnikova1@rambler.ru" class="auth_mail" title="E-mail the corresponding author}
关键词：SH ; severe hypoxia ; HDACs ; histone deacetylases ; HATs ; histone acetyltransferases ; DNMTs ; DNA methyltransferases ; GR ; glucocorticoid receptor ; MR ; mineralocorticoid receptor ; pan-ac ; pan-acetyl proteins ; H3K24ac ; acetylated histone H3 (Lys24)
刊名：Acta Histochemica
出版年：2016
出版时间：March 2016
年：2016
卷：118
期：2
页码：80-89
全文大小：3479 K

文摘

•: Histone acetylation is linked to the activation of gene expression.
•: Injurious hypoxia induces deacetylation of histones in rat brain neurons.
•: Protective hypoxic preconditioning stimulated acetylation of histones in the brain.
•: Acetylation of histones is necessary for development of brain hypoxic tolerance.