Targeting the Janus-activated kinase-2-STAT3 signalling pathway in pancreatic cancer using the HSP90 inhibitor ganetespib

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Targeting the Janus-activated kinase-2-STAT3 signalling pathway in pancreatic cancer using the HSP90 inhibitor ganetespib

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作者：Ganji Purnachandra Nagaraju^a ; Anya Mezina^a ; Walid L. Shaib^a ; Jerome Landry^b ; Bassel F. El-Rayes^a ; ^{belraye@emory.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Pancreatic cancer ; Survival ; Ganetespib ; Chemotherapy
刊名：European Journal of Cancer
出版年：2016
出版时间：January 2016
年：2016
卷：52
期：Complete
页码：109-119
全文大小：1507 K

文摘

•: HSP90 inhibition decreased survival in pancreatic cancer (PC) cells through inhibition of multiple signalling pathways.
•: HSP90 potentiates the antitumour effects of standard chemotherapy agents in PC.
•: Observed effects of HSP90 are mediated through inhibition of Janus-activated kinase-STAT pathway.

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