Canine parvovirus NS1 induced apoptosis involves mitochondria, accumulation of reactive oxygen species and activation of caspases

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Canine parvovirus NS1 induced apoptosis involves mitochondria, accumulation of reactive oxygen species and activation of caspases

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作者：Shishir Kumar Gupta ; ^{shishirgupta.biotech@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Aditya Prasad Sahoo ; Nighil Rosh ; Ravi Kumar Gandham ; Lovleen Saxena ; Arvind Kumar Singh ; DR Harish ; Ashok Kumar Tiwari ; ^{aktiwari63@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Apoptosis ; NS1 ; Parvovirus ; Cancer ; Gene therapy
刊名：Virus Research
出版年：2016
出版时间：2 February 2016
年：2016
卷：213
期：Complete
页码：46-61
全文大小：4607 K

文摘

•: Canine parvovirus NS1 (CPV2.NS1) protein does not activate extrinsic pathway of apoptosis.
•: Expression of CPV2.NS1 results in mitochondrial depolarization and opening of permeability transition pores.
•: CPV2.NS1 induced apoptosis is mitochondria mediated i.e., it proceeds through intrinsic pathway.
•: Expression of CPV2.NS1 also causes accumulation of reactive oxygen species.
•: Inclusion of an anti-oxidant in the medium reduces the extent of apoptosis.

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