Some hormone, cytokine and chemokine levels that change across lifespan vary by cognitive status in male Fischer 344 rats

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Some hormone, cytokine and chemokine levels that change across lifespan vary by cognitive status in male Fischer 344 rats

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作者：Rachel B. Scheinert^a ; ^b ; Aditya Asokan^b ; Asha Rani^c ; ^d ; Ashok Kumar^c ; ^d ; Thomas C. Foster^c ; ^d ; ^{foster1@ufl.edu" class="auth_mail" title="E-mail the corresponding author} ; Brandi K. Ormerod^b ; ^c ; ^d ; ^{bormerod@bme.ufl.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Aging ; Inflammation ; Neuroinflammation ; Memory ; Hippocampus ; Water maze ; xMAP technology ; Cytokines ; Chemokines
刊名：Brain, Behavior, and Immunity
出版年：2015
出版时间：October 2015
年：2015
卷：49
期：Complete
页码：216-232
全文大小：1350 K

文摘

•: Similar numbers of middle-aged and aged rats exhibited memory probe impairments.
•: Some serum, hippocampal and cortical analyte levels quantified changed across lifespan.
•: Candidate serum biomarkers predicted spatial and non-spatial scores in aging rats.
•: Cortical biomarkers generally predicted non-spatial behavioral scores in aging rats.
•: Hippocampal biomarkers predicted spatial scores in aging rats.

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