Type-7 metabotropic glutamate receptors negatively regulate α₁-adrenergic receptor signalling

详细信息    查看全文

• 作者：Luisa Iacovelli^a ; Luisa Di Menna^b ; Daniel Peterlik^c ; Christina Stangl^c ; Rosamaria Orlando^a ; Gemma Molinaro^b ; ¹ ; Antonio De Blasi^d ; Valeria Bruno^a ; ^b ; Giuseppe Battaglia^b ; Peter J. Flor^c ; Nicole Uschold-Schmidt^c ; ; Ferdinando Nicoletti^a ; ^b ; ^{ferdinandonicoletti@hotmail.com}
• 关键词：mGlu7 receptors ; α1-adrenergic receptor ; Stress ; Cross-talk ; G proteins
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：343-353
• 全文大小：645 K
• 卷排序：113

文摘

mGlu7 receptors and α1-adrenergic receptors functionally interact. The interaction is shown in heterologous expression systems, brain tissue and living mice. This interaction is mediated by the βγ-subunits of the Gi proteins. The interaction requires the activation of the MAP kinase pathway. This receptor cross-talk might be targeted in the treatment of stress related disorders.