Recombinant protein production by engineered Escherichia coli in a pressurized airlift bioreactor: A techno-economic analysis

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Recombinant protein production by engineered Escherichia coli in a pressurized airlift bioreactor: A techno-economic analysis

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作者：Gilson Campani^a ; Maurí ; cio Possedente dos Santos^a ; Gabriel Gon&ccedil ; alves da Silva^a ; Antô ; nio Carlos Luperni Horta^a ; ^b ; Alberto Colli Badino^a ; ^b ; Roberto de Campos Giordano^a ; ^b ; Viviane Maimoni Gon&ccedil ; alves^c ; Teresa Cristina Zangirolami^a ; ^b ; ^{teresacz@ufscar.br" class="auth_mail" title="E-mail the corresponding author}
关键词：E. coli ; PspA ; Pressurized airlift ; Dissolved oxygen tension
刊名：Chemical Engineering & Processing
出版年：2016
出版时间：May 2016
年：2016
卷：103
期：Complete
页码：63-69
全文大小：803 K

文摘

•: Performance of pressurized airlift bioreactor assessed for rE. coli cultivation.
•: Recombinant protein productivity reached 240 mg L⁻¹ h⁻¹ at 0.25 MPa.
•: Airlift bioreactor pressurization increases energy efficiency for protein production.
•: Overpressure increases economic efficiency of airlift bioreactor by 2.5 fold.

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