Tissue inhibitor of metalloproteinase-3 (TIMP3) expression decreases during melanoma progression and inhibits melanoma cell migration

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Tissue inhibitor of metalloproteinase-3 (TIMP3) expression decreases during melanoma progression and inhibits melanoma cell migration

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作者：Asha M. Das^a ; ^{a.mooppilmadhamdas@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author} ; Michiel Bolkestein^a ; ¹ ; Thom van der Klok^b ; ¹ ; Charlotte M.C. Oude Ophuis^a ; ¹ ; Cindy E. Vermeulen^a ; Joost A.P. Rens^a ; Winand N.M. Dinjens^b ; Peggy N. Atmodimedjo^b ; Cornelis Verhoef^a ; Senada Koljenović^b ; Ron Smits^c ; Timo L.M. ten Hagen^a ; Alexander M.M. Eggermont^a ; ^d ; ^{alexander.eggermont@gustaveroussy.fr" class="auth_mail" title="E-mail the corresponding author}
关键词：TIMP3 ; Melanoma ; Metastasis ; Migration
刊名：European Journal of Cancer
出版年：2016
出版时间：October 2016
年：2016
卷：66
期：Complete
页码：34-46
全文大小：3155 K

文摘

•: Tissue inhibitor of metalloproteinase-3 (TIMP3) expression in sequential melanoma samples was evaluated by immunohistochemistry.
•: TIMP3 expression decreased with melanoma progression.
•: TIMP3 negatively regulates melanoma cell migration and invasion.

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