Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters

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Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters

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作者：Biola M. Javierre¹ ; ¹¹ ; Oliver S. Burren² ; ¹¹ ; Steven P. Wilder³ ; ¹¹ ; Roman Kreuzhuber³ ; ⁴ ; ⁵ ; ¹¹ ; Steven M. Hill⁶ ; ¹¹ ; Sven Sewitz¹ ; Jonathan Cairns¹ ; Steven W. Wingett¹ ; Csilla Vá ; rnai¹ ; Michiel J. Thiecke¹ ; Frances Burden⁴ ; ⁵ ; Samantha Farrow⁴ ; ⁵ ; Antony J. Cutler² ; Karola Rehnströ ; m⁴ ; ⁵ ; Kate Downes⁴ ; ⁵ ; Luigi Grassi⁴ ; ⁵ ; Myrto Kostadima³ ; ⁴ ; ⁵ ; Paula Freire-Pritchett¹ ; Fan Wang⁶ ; The BLUEPRINT Consortium Joost H. Martens ; Bowon Kim ; Nilofar Sharifi ; Eva M. Janssen-Megens ; Marie-Laure Yaspo ; Matthias Linser ; Alexander Kovacsovics ; Laura Clarke ; David Richardson ; Avik Datta ; Paul Flicek
关键词：gene regulation ; chromosome conformation ; promoter capture Hi-C ; non-coding genetic variation ; disease gene prioritization
刊名：Cell
出版年：2016
出版时间：17 November 2016
年：2016
卷：167
期：5
页码：1369-1384.e19
全文大小：17401 K

文摘

•: High-resolution maps of promoter interactions in 17 human primary blood cell types
•: Interaction patterns are cell type specific and segregate with the hematopoietic tree
•: Promoter-interacting regions enriched for regulatory chromatin features and eQTLs
•: Promoter interactions link non-coding GWAS variants with putative target genes

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