Non-heme dioxygenases in tumor hypoxia: They’re all bound with the same fate

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• 作者：Roy Anindya ^{anindya@iith.ac.in}
• 关键词：Fe(II)/2-oxoglutarate-dependent dioxygenase ; Non-heme dioxygenase ; Hypoxia ; Cancer ; Tumor ; DNA repair ; 1meA ; 3meC ; AlkB ; ALKBH2 ; ALKBH3
• 刊名：DNA Repair
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：49
• 期：Complete
• 页码：21-25
• 全文大小：846 K
• 卷排序：49

文摘

The Human genome encodes several non-heme dioxygenases that require molecular oxygen for their activity. Ample evidence suggests that hypoxia inhibits human non-heme dioxygenase family DNA repair proteins ALKBH2 and ALKBH3. Inhibition of ALKBH2 and ALKBH3 could be one of the contributing factors affecting genomic stability.