Identification of novel alternative splice variants of the BCL2L12 gene in human cancer cells using next-generation sequencing methodology

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Identification of novel alternative splice variants of the BCL2L12 gene in human cancer cells using next-generation sequencing methodology

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作者：Panagiotis G. Adamopoulos ; Christos K. Kontos ; Panagiotis Tsiakanikas ; Andreas Scorilas ; ^{ascorilas@biol.uoa.gr" class="auth_mail" title="E-mail the corresponding author}
关键词：BCL2 family ; Splice variants ; Alternative splicing ; Apoptosis ; NGS
刊名：Cancer Letters
出版年：2016
出版时间：1 April 2016
年：2016
卷：373
期：1
页码：119-129
全文大小：3127 K

文摘

•: Using NGS, novel alternative splicing events of the BCL2L12 gene were uncovered.
•: 50 novel transcript variants of the BCL2L12 gene were discovered.
•: 11 novel transcripts of BCL2L12 are predicted to encode new protein isoforms.
•: The other 39 splice variants are nonsense-mediated mRNA decay (NMD) candidates.

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