Design and synthesis of novel anti-Alzheimer’s agents: Acridine-chromenone and quinoline-chromenone hybrids

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Design and synthesis of novel anti-Alzheimer’s agents: Acridine-chromenone and quinoline-chromenone hybrids

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作者：Zahra Najafi^a ; Mina Saeedi^b ; ^c ; Mohammad Mahdavi^d ; Reyhaneh Sabourian^c ; Mahnaz Khanavi^e ; Maliheh Barazandeh Tehrani^a ; Farshad Homayouni Moghadam^f ; Najmeh Edraki^g ; Elahe Karimpor-Razkenari^c ; Mohammad Sharifzadeh^h ; Alireza Foroumadiⁱ ; Abbas Shafieeⁱ ; Tahmineh Akbarzadeh^a ; ^c ; ^{akbarzad@tums.ac.ir" class="auth_mail" title="E-mail the corresponding author}
关键词：Acridine-chromenone ; Alzheimer&rsquo ; s disease ; Anti-cholinesterase ; Docking study ; Neuroprotective activity ; Quinoline-chromenone ; β-Secretase inhibitor
刊名：Bioorganic Chemistry
出版年：2016
出版时间：August 2016
年：2016
卷：67
期：Complete
页码：84-94
全文大小：1150 K

文摘

•: Seventeen novel acridine-chromenone and quinoline-chromenone hybrids were designed and synthesized.
•: All of them were evaluated for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity.
•: Among them, compound (8e) exhibited the most potent inhibitory activity: IC₅₀ = 16.17 μM.
•: The most active compound was evaluated for β-secretase and neuroprotective activities.

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