Host-to-Host Transmission of Streptococcus pneumoniae Is Driven by Its Inflammatory Toxin, Pneumolysin

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• 作者：M. Ammar Zafar<sup>1sup><sup> ; sup><sup>3sup> ; Yang Wang<sup>2sup><sup> ; sup><sup>1sup><sup> ; sup><sup>3sup> ; Shigeto Hamaguchi<sup>1sup> ; Jeffrey N. Weiser<sup>1sup><sup> ; sup><sup>4sup><sup> ; sup><sup>jeffrey.weiser@nyumc.orgsup>
• 关键词：transmission ; pneumococcus ; pneumolysin ; colonization ; bacteria ; toxin ; shedding ; infection
• 刊名：Cell Host & Microbe
• 出版年：2017
• 出版时间：11 January 2017
• 年：2017
• 卷：21
• 期：1
• 页码：73-83
• 全文大小：2436 K
• 卷排序：21

文摘

Shedding of colonizing S. pneumoniae from mice correlates with mucosal inflammation The pneumococcal toxin pneumolysin promotes mucosal inflammation Pneumolysin expression is required for pup-to-pup transmission of S. pneumoniae Ex vivo survival of pneumococci is affected by pneumolysin expression in the donor